membrane filter

IRI: https://spec.industrialontologies.org/ontology/construct/MembraneFilter

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaEquipment/

SubClass Of: filter

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › bfo:object › material artifact › filter › membrane filter

Definition

filter consisting of one or more flat or pleated porous layers made from polymers, that has a defined pore size enabling the removal of particles from liquids by (physical exclusion) sieving or surface adsorption

Explanatory Notes

1) Typical requirements of membrane filters used in the production of protein pharmaceuticals are (1) low adsorption of protein to the filter membrane, (2) high total liquid throughput, (3) minimum fouling of the filter, and (4) fulfillment of all applicable regulatory requirements. 2) These filters are used in biopharmaceutical manufacturing for purposes including bioburden control, virus retention, concentration, and buffer exchange. They are employed across multiple unit operations, including sterilizing filtration (e.g., 0.2-micron for aseptic processing), mycoplasma protection (e.g., 0.1-micron), and high-throughput buffer filtration, and may feature multi-layer or single-layer constructions to meet specific performance requirements such as flux and capacity 3) Examples of polymers used for membrane filters are surface-modified polyether sulfones

Examples

  • “Regenerated cellulose;PES; Amicon® Ultra”

Counter-Examples

  • Metal filters;Activated carbon sheets;Glass fibers

Adapted From

  • https://link.springer.com/chapter/10.1007/978-1-4615-0549-5_5 and https://www.biopharminternational.com/view/advances-in-filtration-technology and https://www.iso.org/obp/ui#iso:std:iso:7704:ed-2:v1:en:term:3.1.1

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There are insufficient constructs in the ontology to create necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms 

MembraneFilter(x) → Filter(x)

Semi-Formal Natural Language Axioms

if x is a ‘membrane filter’ then x is a ‘filter’

Description Logic

constr:MembraneFilter ⊑ constr:Filter

constr:MembraneFilter ⊓ constr:DepthFilter ⊑ ⊥

SubClassOf: constr:Filter

constr:MembraneFilter DisjointWith: constr:DepthFilter