cell culture

IRI: https://spec.industrialontologies.org/ontology/construct/CellCulture

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/

SubClass Of: bfo:material entity

Class Hierarchy

owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › cell culture

Definition

material entity that has cultured cells and the media in which they are being propagated or stored as parts

Explanatory Notes

A cell culture includes the cells in culture, as well as the media and all additives in which the cells are being grown or in which they are stored.

Examples

  • CHO Suspension Culture in CD-CHO Medium; HEK293 Monolayer in DMEM + 10% FBS;

Counter-Examples

  • In situ cells are observed and studied within their natural tissue context without being cultured or removed, e.g., neurons, alveolar epithelial cells; Post-centrifugation cell pellet; Uninoculated Culture Medium; Glass Slide with Fixed Cells (No Live Media); Tissue Biopsy in PBS Buffer

Synonyms

  • culture broth

Adapted From

  • OBI:0001876

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

There is currently a lack of a constituency relation (is made of) in this release. It is expected that that relation will be available in the next release of IOF Core

Formal Axioms

First-Order Logic Axioms 

CellCulture(x) → MaterialEntity(x) ∧ ∃y (CultureMedium(y) ∧ hasContinuantPartAtAllTimes(x, y)) ∧ ∃z (CulturedCellPopulation(z) ∧ hasContinuantPartAtAllTimes(x, z))

Semi-Formal Natural Language Axioms

if x is a ‘cell culture’ then x is a ‘material entity’ and x ‘has continuant part at all times’ some ‘culture medium’ and x ‘has continuant part at all times’ some ‘cultured cell population’

Description Logic

constr:CellCulture ⊑ bfo:material_entity

constr:CellCulture ⊑ ∃ bfo:has_continuant_part_at_all_times .constr:CultureMedium

constr:CellCulture ⊑ ∃ bfo:has_continuant_part_at_all_times .constr:CulturedCellPopulation

constr:CellCulture ⊓ constr:Cell ⊑ ⊥

constr:CellCulture ⊓ constr:CultureMedium ⊑ ⊥

constr:CellCulture ⊓ constr:CulturedCellPopulation ⊑ ⊥

SubClassOf: bfo:material_entity

SubClassOf: bfo:has_continuant_part_at_all_times some constr:CultureMedium

SubClassOf: bfo:has_continuant_part_at_all_times some constr:CulturedCellPopulation

constr:CellCulture DisjointWith: (constr:Cell, constr:CultureMedium, constr:CulturedCellPopulation)