clone selection process
IRI: https://spec.industrialontologies.org/ontology/construct/CloneSelectionProcess
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/
SubClass Of: planned process
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › clone selection process
Definition
planned processs in which an optimal set of cell clones is identified and isolated based on the clones exibiting desirable characteristics
Explanatory Notes
Desirable characteristics can be things such as high protein expression levels, consistent product quality, and robust growth
Examples
- using microscope images from clone experiments as input to a predictive model to prioritize clones, followed by selecting candidates with optimal morphology and expression levels; selecting clones based on functional assays confirming high target protein activity and long-term culture stability; manually screening clones under a microscope and selecting those with optimal morphology and growth behavior
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
Insufficient constructs are present to create a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
CloneSelectionProcess(x) → PlannedProcess(x) ∧ ∃y (ClonedCellLine(y) ∧ hasSpecifiedOutput(x, y))
Semi-Formal Natural Language Axioms
if x is a ‘clone selection process’ then x is a ‘planned process’ and ‘has specified output’ some ‘cloned cell line’