cell line
IRI: https://spec.industrialontologies.org/ontology/construct/CellLine
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaMaterial/
SubClass Of: cultured cell population
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › bfo:object aggregate › cell population › cultured cell population › cell line
Direct subclasses:
Definition
cultured cell population that is derived from a primary cell source and that has been propagated through repeated subculture under defined conditions, resulting in a genetically stable and homogeneous population of cells with a shared propagation history
Explanatory Notes
1) A cell line is typically stored in a cell bank and used to ensure consistent and reproducible performance across experimental or manufacturing contexts. 2) The term excludes freshly isolated or short-lived primary cultures.
Examples
- HeLa cells; HEK293 cells; Vero cells
Adapted From
- CLO:0000031 and https://www.fda.gov/media/78428/download
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
There are insufficient constructs to define necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
CellLine(x) → CulturedCellPopulation(x)
Semi-Formal Natural Language Axioms
if x is a ‘cell line’ then x is a ‘cultured cell population’