biomanufacturing production process
IRI: https://spec.industrialontologies.org/ontology/construct/BiomanufacturingProductionProcess
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/
SubClass Of: manufacturing process
Class Hierarchy
owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › manufacturing process › biomanufacturing production process
Direct subclasses:
Definition
manufacturing process in which biological entities such as cells, enzymes, or organisms are used to synthesize, secrete, accumulate, or themselves serve as the target product
Explanatory Notes
1) The target products may include proteins, nucleic acids, metabolites, or whole cells 2) This construct is labeled as a biomanufacturing production process and is distinct from a full product production process. In a biomanufacturing production process, the desired biological product is synthesized, secreted, or accumulated by a biological system. At this stage, the product is typically present in a complex mixture containing process-related and product-related impurities. Additional processing steps such as purification, concentration, and formulation are generally required to isolate the product and prepare it in its final usable form.
Examples
- recombinant protein expression using CHO cells; monoclonal antibody production in a bioreactor; viral vector production using HEK293 cells; fermentation process for production of penicillin by Penicillium chrysogenum; mRNA synthesis using enzymatic in vitro transcription;
Primitive Class
This class is declared primitive and it does not have necessary and sufficient condiftions defined.
Primitive Rationale
Insufficient constructs are present to create a set of necessary and sufficient conditions.
Formal Axioms
First-Order Logic Axioms
BiomanufacturingProductionProcess(x) → ManufacturingProcess(x)
Semi-Formal Natural Language Axioms
if x is a ‘biomanufacturing production process’ then x is a ‘manufacturing process’