chromatography system
IRI: https://spec.industrialontologies.org/ontology/construct/ChromatographySystem
Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaEquipment/
SubClass Of: engineered system
Class Hierarchy
owl:Thing › bfo:entity › bfo:continuant › bfo:independent continuant › bfo:material entity › bfo:object aggregate › system › engineered system › chromatography system
Direct subclasses:
Definition
engineered system designed to control the fluid flow of the mobile phase provide monitoring or detection capabilities and house or interface with the stationary phase for one or more chromatography processes
Semi-Formal Definition:
every instance of ‘chromatography system’ is defined as exactly an instance of ‘engineered system’ that ‘has member part at some time’ some ‘stationary phase’, ‘has capability’ some ‘measurement capability’, and ‘has function’ some ‘flow rate controlling capability’
Explanatory Notes
1.Chromatography systems typically include hardware for sample introduction, flow control, and detection, as well as software interfaces for configuring, monitoring, and automating purification processes across research, clinical, and manufacturing scales. Monitoring may include pH, conductivity, pressure, temperature, or other relevant parameters associated with the separation process. 2.Chromatography systems are available as single-use or multi-use models to accommodate different operational requirements and separation needs across laboratory, clinical, and manufacturing scales.
- The phrase “house or interface with the stationary phase” refers to the system’s ability either to physically contain the stationary phase directly (e.g., in built-in columns or integrated cartridges) or to connect to and operate with external components that contain the stationary phase, such as detachable chromatography columns. This accommodates both fully integrated and modular system designs, ensuring that the stationary phase is part of the fluid path during the chromatography process
Examples
- AKTA FPLC Chromatography systems such as AKTA pure and AKTAprime plus; Agilent Gas Chromatography System; Vanquish HPLC and UHPLC Systems
Adapted From
- http://wolfson.huji.ac.il/purification/PDF/affinity/GE_Affinity_Chromatography_Handbook-Antibodies.pdf https://www.cytivalifesciences.com/en/us/shop/chromatography/chromatography-systems?sort=NameAsc&chunk=1 and https://biocev.lf1.cuni.cz/file/282/protein-purification-handbook.pdf
Formal Axioms
First-Order Logic Definition
ChromatographySystem(x) ↔ EngineeredSystem(x) ∧ ∃s(StationaryPhase(s) ∧ hasMemberPartAtSomeTime(x, s)) ∧ ∃c(MeasurementCapability(c) ∧ hasCapability(x, c)) ∧ ∃f(FlowRateControllingCapability(f) ∧ hasFunction(x, f))
Description Logic
constr:ChromatographySystem ≡ constr:EngineeredSystem ⊓ ∃ bfo:has_member_part .constr:StationaryPhase ⊓ ∃ constr:hasCapability .constr:MeasurementCapability ⊓ ∃ constr:hasFunction .constr:FlowRateControllingCapability
constr:ChromatographySystem ⊑ constr:EngineeredSystem
EquivalentTo: constr:EngineeredSystem and bfo:has_member_part some constr:StationaryPhase and constr:hasCapability some constr:MeasurementCapability and constr:hasFunction some constr:FlowRateControllingCapability
SubClassOf: constr:EngineeredSystem
constr:ChromatographySystem DisjointWith: (constr:Bioreactor, constr:ThawingSystem)