cell culture expansion process

IRI: https://spec.industrialontologies.org/ontology/construct/CellCultureExpansionProcess

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: planned process

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › cell culture expansion process

Definition

planned process in which cells within a cell culture proliferate, resulting in an increase in the total cell number

Explanatory Notes

Implicit in cell culture expansion is the assumption that cells in culture remain healthy and proliferative. This assumption is typically evaluated by monitoring cell viability, which serves as a key indicator of culture fitness.

Examples

  • Shake flask expansion of CHO cells with controlled feeding and monitoring; seed train expansion of hematopoietic stem cells under GMP conditions; fed-batch bioreactor expansion of hybridoma cells with automated pH and DO control; scale-up culture of mammalian cells in rocking bioreactors with defined agitation parameters; T cell expansion in gas-permeable bags with scheduled media additions

Counter-Examples

  • proliferation of cells caused by a contamination

Adapted From

  • OBI:0001147

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

Insufficient constructs are present to create a set of necessary and sufficient conditions.

Formal Axioms

First-Order Logic Axioms 

if x is a 'cell culture expansion process' then x is a 'planned process' that 'has input' some 'cell culture' and 'has occurrent part' some 'cell population proliferation'

Semi-Formal Natural Language Axioms

CellCultureExpansionProcess(x) → PlannedProcess(x) ∧ ∃y (CellCulture(y) ∧ hasInput(x, y)) ∧ ∃z (CellPopulationProliferation(z) ∧ hasOccurrentPart(x, z))

Description Logic

constr:CellCultureExpansionProcess ⊑ constr:PlannedProcess

constr:CellCultureExpansionProcess ⊑ ∃ bfo:has_occurrent_part .constr:CellPopulationProliferation

constr:CellCultureExpansionProcess ⊑ ∃ constr:hasInput .constr:CellCulture

SubClassOf: constr:PlannedProcess

SubClassOf: bfo:has_occurrent_part some constr:CellPopulationProliferation

SubClassOf: constr:hasInput some constr:CellCulture