cell population proliferation

IRI: https://spec.industrialontologies.org/ontology/construct/CellPopulationProliferation

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: bfo:process

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › cell population proliferation

Definition

process in which cells reproduce or multiply, resulting in an increase in the number of cells

Examples

  • natural proliferation of skin fibroblasts during wound healing; proliferation of T cells upon antigen stimulation in immune response; bacterial population growth in a nutrient-rich medium; uncontrolled cancer cell proliferation in tumor tissue; multiplication of yeast cells during fermentation

Synonyms

  • cell population growth

Adapted From

  • GO:0008283

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

This term is expected to remain primitive. Details of cellular reproduction or multiplications are out of scope and should be utilized if needed from a biological ontology.

Formal Axioms

First-Order Logic Axioms 

CellPopulationProliferation(x) → Process(x) ∧ ∃y (CellPopulation(y) ∧ hasParticipantAtAllTimes(x, y))

Semi-Formal Natural Language Axioms

if x is a ‘cell population proliferation’ then x is a ‘process’ that ‘has participant at all times’ some ‘cell population’

Description Logic

constr:CellPopulationProliferation ⊑ bfo:process

constr:CellPopulationProliferation ⊑ ∃ bfo:has_participant_at_all_times .constr:CellPopulation

SubClassOf: bfo:process

SubClassOf: bfo:has_participant_at_all_times some constr:CellPopulation