chromatography process

IRI: https://spec.industrialontologies.org/ontology/construct/ChromatographyProcess

Defined In: https://spec.industrialontologies.org/ontology/biopharma/BiopharmaManufacturingExecution/

SubClass Of: planned process

Class Hierarchy

owl:Thing › bfo:entity › bfo:occurrent › bfo:process › planned process › chromatography process

Direct subclasses:

Definition

planned process that results in the separation of components in a mixture based on their distribution between two phases, one of which is stationary and the other moves in a definite direction

Explanatory Notes

The phase moving in a definite direction is called a mobile phase and is a fluid

Examples

  • In the recombinant human insulin manufacturing process, a Size Exclusion Chromatography (SEC) process is used for the final polishing step using Sephadex G-25 to remove salts and ensure the proper molecular weight distribution of insulin; Industrial plants devoted to the processing of Corn use a continuous simulated moving bed (SMB) chromatography process to separate fructose from glucose

Adapted From

  • CHMO:0001000

Primitive Class

This class is declared primitive and it does not have necessary and sufficient condiftions defined.

Primitive Rationale

Insufficient constructs are present to create a set of necessary and sufficient conditions

Formal Axioms

First-Order Logic Axioms 

ChromatographyProcess(x) → PlannedProcess(x) ∧ ∃y (MobilePhase(y) ∧ hasParticipantAtSomeTime(x, y)) ∧ ∃z (StationaryPhase(z) ∧ hasParticipantAtSomeTime(x, z))

Semi-Formal Natural Language Axioms

if x is a ‘chromatography process’ then x is a ‘planned process’ that ‘has participant at some time’ some ‘mobile phase’ and ‘has participant at some time’ some ‘stationary phase’

Description Logic

constr:ChromatographyProcess ⊑ constr:PlannedProcess

constr:ChromatographyProcess ⊑ ∃ bfo:has_participant .constr:MobilePhase

constr:ChromatographyProcess ⊑ ∃ bfo:has_participant .constr:StationaryPhase

SubClassOf: constr:PlannedProcess

SubClassOf: bfo:has_participant some constr:MobilePhase

SubClassOf: bfo:has_participant some constr:StationaryPhase